{"id":317,"date":"2020-01-20T03:20:16","date_gmt":"2020-01-20T03:20:16","guid":{"rendered":"http:\/\/paoloaltoe.com.br\/blog\/?p=317"},"modified":"2020-01-20T21:16:13","modified_gmt":"2020-01-20T21:16:13","slug":"sintese-de-proteina-insulina-whey-protein-leucina-bcaa","status":"publish","type":"post","link":"https:\/\/paoloaltoe.com.br\/blog\/2020\/01\/20\/sintese-de-proteina-insulina-whey-protein-leucina-bcaa\/","title":{"rendered":"S\u00cdNTESE DE PROTE\u00cdNA – INSULINA, WHEY PROTEIN, LEUCINA, BCAA"},"content":{"rendered":"\t\t
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Em condi\u00e7\u00e3o de infus\u00e3o constante de amino\u00e1cidos, ir al\u00e9m de determinado liminar de insulina N\u00c3O promove
maiores redu\u00e7\u00f5es na quebra proteica. O curioso \u00e9 que tamb\u00e9m N\u00c3O promove maior s\u00edntese de prote\u00edna, como voc\u00ea pode observar na imagem (1<\/a>).<\/p>\t\t\t\t\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t\t<\/div>\n\t\t<\/div>\n\t\t\t\t\t<\/div>\n\t\t<\/section>\n\t\t\t\t

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V\u00e1lido apontar que se n\u00e3o houvesse a oferta constante de amino\u00e1cidos, mas somente a adi\u00e7\u00e3o ex\u00f3gena de insulina, ocorreria um estado de hipoaminoacidemia, o qual REDUZIRIA s\u00edntese de prote\u00edna (2<\/a>–3<\/a>).
Nesse sentido, embora a insulina exer\u00e7a a\u00e7\u00e3o anticatab\u00f3lica, seus efeitos no aumento de s\u00edntese prote\u00edca por si s\u00f3 dependem de n\u00edveis suprafisiol\u00f3gicos (2-3).
Para efeitos de quantifica\u00e7\u00e3o, a maior dose de insulina utilizada no estudo (1<\/a>), foi de 1160 pmol\/L. Dose suprafisiol\u00f3gica modulando s\u00edntese de prote\u00edna para cima: 50.000 pmol\/L (2<\/a>).<\/p>


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At\u00e9 aqui voc\u00ea j\u00e1 sabe que, em contextos fisiol\u00f3gicos, n\u00e3o h\u00e1 necessidade de “pico de insulina”, seja para reduzir quebra,
seja para aumentar s\u00edntese de prote\u00edna. Uma pequena quantidade de insulina, ~210-1160 pmol\/L, j\u00e1 cumpre com maestria seu papel (1<\/a>).<\/p>


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Em texto anterior avaliamos que a adi\u00e7\u00e3o de carboidratos ao shake de prote\u00edna p\u00f3s treino N\u00c3O promove maior reten\u00e7\u00e3o de nitrog\u00eanio comparado ao shake contendo somente prote\u00edna (4<\/a>).
Agora voc\u00ea quer saber: E adicionar leucina ou bcaa ao shake de prote\u00edna?<\/strong><\/p>\t\t\t\t\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t\t<\/div>\n\t\t<\/div>\n\t\t\t\t\t<\/div>\n\t\t<\/section>\n\t\t\t\t

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O estudo (5<\/a>) investigou os efeitos do consumo de 5 tipos de shakes p\u00f3s treino na s\u00edntese de prote\u00edna.
Todos os shakes continham 241kcal e 5,68g em gordura. 35g de carbos exceto para grupo W25, que ficou com 22,9g.
Composi\u00e7\u00e3o detalhada dos shakes e os resultados na segunda imagem.<\/p>\t\t\t\t\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t\t<\/div>\n\t\t<\/div>\n\t\t\t\t\t<\/div>\n\t\t<\/section>\n\t\t\t\t

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CONCLUS\u00c3O:<\/strong> Os autores interpretaram os resultados sugerindo que adicionar leucina\/bcaa ao shake de prote\u00edna seja uma estrat\u00e9gia v\u00e1lida para estimular e manter s\u00edntese de prote\u00edna.
Na verdade, o que fica evidente \u00e9 a inutilidade da adi\u00e7\u00e3o de leucina\/bcaa em uma situa\u00e7\u00e3o onde h\u00e1 quantidade adequada de prote\u00edna de alto valor biol\u00f3gico.
NOTA: S\u00edntese de prote\u00edna n\u00e3o significa hipertrofia.
Mede-se a s\u00edntese pois a quebra \u00e9 facilmente suprimida, como visto anteriormente (6<\/a>).<\/p>\t\t\t\t\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t\t<\/div>\n\t\t<\/div>\n\t\t\t\t\t<\/div>\n\t\t<\/section>\n\t\t\t\t

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REFER\u00caNCIAS BIBLIOGR\u00c1FICAS:<\/strong><\/p>

(1) – https:\/\/physiology.org\/doi\/full\/10.1152\/ajpendo.90411.2008
(2) – https:\/\/www.ncbi.nlm.nih.gov\/pubmed\/25646407
(3) – https:\/\/link.springer.com\/article\/10.1007\/s00125-015-3751-0
(4) – http:\/\/paoloaltoe.com.br\/blog\/2020\/01\/18\/sintese-de-proteinas-ha-necessidade-de-adicionar-carboidratos\/
(5) – https:\/\/www.ncbi.nlm.nih.gov\/pubmed\/24284442
(6) – http:\/\/paoloaltoe.com.br\/blog\/2020\/01\/19\/proteina-maxima-resposta-anabolica\/<\/p>\t\t\t\t\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t\t<\/div>\n\t\t<\/div>\n\t\t\t\t\t<\/div>\n\t\t<\/section>\n\t\t\t\t

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Em condi\u00e7\u00e3o de infus\u00e3o constante de amino\u00e1cidos, ir al\u00e9m de determinado liminar de insulina N\u00c3O promove maiores redu\u00e7\u00f5es na quebra proteica. O curioso \u00e9 que tamb\u00e9m N\u00c3O promove maior s\u00edntese de prote\u00edna, como voc\u00ea pode observar na imagem (1). V\u00e1lido apontar que se n\u00e3o houvesse a oferta constante de amino\u00e1cidos, mas somente a adi\u00e7\u00e3o ex\u00f3gena […]<\/p>\n","protected":false},"author":1,"featured_media":0,"comment_status":"open","ping_status":"open","sticky":false,"template":"","format":"standard","meta":{"_monsterinsights_skip_tracking":false,"_monsterinsights_sitenote_active":false,"_monsterinsights_sitenote_note":"","_monsterinsights_sitenote_category":0,"footnotes":""},"categories":[110,8],"tags":[106,103,108,107,55,68,54,105,50,49,104],"_links":{"self":[{"href":"https:\/\/paoloaltoe.com.br\/blog\/wp-json\/wp\/v2\/posts\/317"}],"collection":[{"href":"https:\/\/paoloaltoe.com.br\/blog\/wp-json\/wp\/v2\/posts"}],"about":[{"href":"https:\/\/paoloaltoe.com.br\/blog\/wp-json\/wp\/v2\/types\/post"}],"author":[{"embeddable":true,"href":"https:\/\/paoloaltoe.com.br\/blog\/wp-json\/wp\/v2\/users\/1"}],"replies":[{"embeddable":true,"href":"https:\/\/paoloaltoe.com.br\/blog\/wp-json\/wp\/v2\/comments?post=317"}],"version-history":[{"count":11,"href":"https:\/\/paoloaltoe.com.br\/blog\/wp-json\/wp\/v2\/posts\/317\/revisions"}],"predecessor-version":[{"id":357,"href":"https:\/\/paoloaltoe.com.br\/blog\/wp-json\/wp\/v2\/posts\/317\/revisions\/357"}],"wp:attachment":[{"href":"https:\/\/paoloaltoe.com.br\/blog\/wp-json\/wp\/v2\/media?parent=317"}],"wp:term":[{"taxonomy":"category","embeddable":true,"href":"https:\/\/paoloaltoe.com.br\/blog\/wp-json\/wp\/v2\/categories?post=317"},{"taxonomy":"post_tag","embeddable":true,"href":"https:\/\/paoloaltoe.com.br\/blog\/wp-json\/wp\/v2\/tags?post=317"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}