{"id":372,"date":"2020-01-20T21:31:57","date_gmt":"2020-01-20T21:31:57","guid":{"rendered":"http:\/\/paoloaltoe.com.br\/blog\/?p=372"},"modified":"2020-01-20T21:39:27","modified_gmt":"2020-01-20T21:39:27","slug":"creatina-alem-do-aparente","status":"publish","type":"post","link":"https:\/\/paoloaltoe.com.br\/blog\/2020\/01\/20\/creatina-alem-do-aparente\/","title":{"rendered":"CREATINA AL\u00c9M DO APARENTE"},"content":{"rendered":"\t\t
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O sistema creatina quinase (CK) – fosfocreatina (PCr) est\u00e1 envolvido em uma infinidade de processos bioenerg\u00e9ticos e sua express\u00e3o e import\u00e2ncia aumenta em c\u00e9lulas de maior\u00a0 demanda energ\u00e9tica, como as musculares esquel\u00e9ticas, card\u00edacas e lisas, dos rins, do c\u00e9rebro\/neur\u00f4nios,\u00a0 de fotoreceptores\/retina, e at\u00e9 espermatozoides (1<\/a>–2<\/a>).<\/p>

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Pode-se designar que a regula\u00e7\u00e3o desse sistema enzim\u00e1tico opera em compartimenta\u00e7\u00f5es subcelulares, especificamente
no local onde a energia ser\u00e1 produzida (glic\u00f3lise, fosforila\u00e7\u00e3o oxidativa) ou utilizada (ATPases, canais i\u00f4nicos, eventos dependentes de ATP), atuando como regulador da homeostase energ\u00e9tica em n\u00edvel celular (1<\/a>–2<\/a>).<\/p>

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A s\u00edntese end\u00f3gena ocorre predominantemente no f\u00edgado utilizando os amino\u00e1cidos arginina e glicina, mas tamb\u00e9m requer um doador de metil, a S-adenosil-metionina (3<\/a>). A s\u00edntese resulta em ~1g ao dia e, com a alimenta\u00e7\u00e3o, temos mais 1g de creatina \u00e0 disposi\u00e7\u00e3o. A excre\u00e7\u00e3o renal di\u00e1ria gira em torno de 2g (4<\/a>).<\/p>\t\t\t\t\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t\t<\/div>\n\t\t<\/div>\n\t\t\t\t\t<\/div>\n\t\t<\/section>\n\t\t\t\t

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At\u00e9 aqui voc\u00ea percebe que para que as compartimenta\u00e7\u00f5es de creatina sejam aumentadas, h\u00e1 a necessidade de suplementa\u00e7\u00e3o. Tamb\u00e9m que em situa\u00e7\u00f5es de disfuncionalidade bioenerg\u00e9tica\/mitocondrial, essa suplementa\u00e7\u00e3o teria potencial terap\u00e8utico\/preventivo e ainda que os tecidos\/\u00f3rg\u00e3os mais ativos seriam aqueles que mais se beneficiariam disso.<\/p>

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Alguns destaques:<\/strong>
Efeito neuroprotetivo (5<\/a>, 6<\/a>, 7<\/a>);
Anti-inflamat\u00f3rio (8<\/a>, 9<\/a>, 10<\/a>);
Sa\u00fade mitocondrial (11<\/a>);
Antioxidante (12<\/a>).<\/p>\t\t\t\t\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t\t<\/div>\n\t\t<\/div>\n\t\t\t\t\t<\/div>\n\t\t<\/section>\n\t\t\t\t

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REFER\u00caNCIAS BIBLIOGR\u00c1FICAS:<\/strong>
(1) – Biochem J. 1992 Jan 1; 281(Pt 1): 21\u201340
(2) – Saks VA (ed) Molecular systems bioenergetics: energy forlife. Wiley, Weinheim, pp 195\u2013264
(3) – Physiol Rev. 2000 Jul;80(3):1107-213.
(4) – Volek J.S., Ballard K.D., Forsythe C.E. (2008) Overview of Creatine Metabolism. In: Stout J.R., Antonio J., Kalman D. (eds)
Essentials of Creatine in Sports and Health. Humana Press
(5) – Ann Neurol. 2000 Nov;48(5):723-9.
(6) – J Neurochem. 2000 May;74(5):1968-78
(7) – Amino Acids. 2002;23(1-3):221-9.
(8) – Arch Int Pharmacodyn Ther. 1978 Feb;231(2):340-50
(9) – Amino Acids. 2008 Aug;35(2):425-31. Epub 2007 Oct 4.
(10) – Int Immunopharmacol. 2011 Sep; 11(9): 1341\u20131347.
(11) – Mol Cell Biochem. 1997 Sep;174(1-2):283-9.
(12) – Biochem Biophys Res Commun. 2002 Jan 11;290(1):47-52.<\/p>\t\t\t\t\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t\t<\/div>\n\t\t<\/div>\n\t\t\t\t\t<\/div>\n\t\t<\/section>\n\t\t\t\t

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O sistema creatina quinase (CK) – fosfocreatina (PCr) est\u00e1 envolvido em uma infinidade de processos bioenerg\u00e9ticos e sua express\u00e3o e import\u00e2ncia aumenta em c\u00e9lulas de maior  demanda energ\u00e9tica, como as musculares esquel\u00e9ticas, card\u00edacas e lisas, dos rins, do c\u00e9rebro\/neur\u00f4nios,  de fotoreceptores\/retina, e at\u00e9 espermatozoides (1–2). Pode-se designar que a regula\u00e7\u00e3o desse sistema enzim\u00e1tico opera em […]<\/p>\n","protected":false},"author":1,"featured_media":0,"comment_status":"open","ping_status":"open","sticky":false,"template":"","format":"standard","meta":{"_monsterinsights_skip_tracking":false,"_monsterinsights_sitenote_active":false,"_monsterinsights_sitenote_note":"","_monsterinsights_sitenote_category":0,"footnotes":""},"categories":[110,8,7],"tags":[42,124,123,129,122,128,126,127],"_links":{"self":[{"href":"https:\/\/paoloaltoe.com.br\/blog\/wp-json\/wp\/v2\/posts\/372"}],"collection":[{"href":"https:\/\/paoloaltoe.com.br\/blog\/wp-json\/wp\/v2\/posts"}],"about":[{"href":"https:\/\/paoloaltoe.com.br\/blog\/wp-json\/wp\/v2\/types\/post"}],"author":[{"embeddable":true,"href":"https:\/\/paoloaltoe.com.br\/blog\/wp-json\/wp\/v2\/users\/1"}],"replies":[{"embeddable":true,"href":"https:\/\/paoloaltoe.com.br\/blog\/wp-json\/wp\/v2\/comments?post=372"}],"version-history":[{"count":3,"href":"https:\/\/paoloaltoe.com.br\/blog\/wp-json\/wp\/v2\/posts\/372\/revisions"}],"predecessor-version":[{"id":376,"href":"https:\/\/paoloaltoe.com.br\/blog\/wp-json\/wp\/v2\/posts\/372\/revisions\/376"}],"wp:attachment":[{"href":"https:\/\/paoloaltoe.com.br\/blog\/wp-json\/wp\/v2\/media?parent=372"}],"wp:term":[{"taxonomy":"category","embeddable":true,"href":"https:\/\/paoloaltoe.com.br\/blog\/wp-json\/wp\/v2\/categories?post=372"},{"taxonomy":"post_tag","embeddable":true,"href":"https:\/\/paoloaltoe.com.br\/blog\/wp-json\/wp\/v2\/tags?post=372"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}